Modified Nucleosides
N3-Methyl-2'-O-methyluridine
Quick view. A uridine nucleoside bearing N3-methyl and 2'-O-methyl modifications, identified by CAS 7103-27-7. CAS 7103-27-7. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
N3-Methyl-2'-O-methyluridine is classified as modified nucleosides (Formula C11H16N2O6; molecular weight 272.25).
N3-Methyl-2'-O-methyluridine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For N3-Methyl-2'-O-methyluridine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Useful catalog search terms
- CAS 7103-27-7
- PubChem CID 66763497
Physicochemical data
| Nucleobase modification | N3-methyl |
|---|---|
| Sugar modification | 2'-O-methyl |
| InChIKey | OTFGHFBGGZEXEU-PEBGCTIMSA-N |
| PubChem CID | 66763497 |
| InChI | InChI=1S/C11H16N2O6/c1-12-7(15)3-4-13(11(12)17)10-9(18-2)8(16)6(5-14)19-10/h3-4,6,8-10,14,16H,5H2,1-2H3/t6-,8-,9-,10-/m1/s1 |
| SMILES | CN1C(=O)C=CN(C1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)OC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe N3-Methyl-2'-O-methyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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