Protected Nucleosides
N4-Benzoyl-5'-O-DMTr-2',2'-difluoro-2'-deoxycytidine
Quick view. An N4-benzoyl- and 5'-O-DMTr-protected 2',2'-difluoro-2'-deoxycytidine derivative, CAS 142808-43-3. CAS 142808-43-3. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
N4-Benzoyl-5'-O-DMTr-2',2'-difluoro-2'-deoxycytidine is classified as protected nucleosides (Formula C37H33F2N3O7; molecular weight 669.67).
N4-Benzoyl-5'-O-DMTr-2',2'-difluoro-2'-deoxycytidine — A doubly protected 2',2'-difluoro-2'-deoxycytidine intermediate for research use in nucleoside synthesis.
For N4-Benzoyl-5'-O-DMTr-2',2'-difluoro-2'-deoxycytidine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- N4-Benzoyl-2'-deoxy-5'-O-DMTr-2',2'-difluorocytidine
- N4-Bz-5'-O-DMTr-2',2'-diF-dC
Useful catalog search terms
- 142808-43-3
Physicochemical data
| Systematic name | N-(1-((2R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,3-difluoro-4-hydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide |
|---|---|
| SMILES | COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OC[C@@H]4[C@H](C([C@@H](O4)N5C=CC(=NC5=O)NC(=O)C6=CC=CC=C6)(F)F)O |
| Nucleoside | 2',2'-Difluoro-2'-deoxycytidine |
| Base protection | N4-Benzoyl |
| 5' protection | DMTr |
| Hydroxyl state | Free 3'-OH |
| PubChem CID | 121300044 |
| InChIKey | WTSBHVUMDHCRKO-LIAFXSCVSA-N |
| InChI | InChI=1S/C37H33F2N3O7/c1-46-28-17-13-26(14-18-28)36(25-11-7-4-8-12-25,27-15-19-29(47-2)20-16-27)48-23-30-32(43)37(38,39)34(49-30)42-22-21-31(41-35(42)45)40-33(44)24-9-5-3-6-10-24/h3-22,30,32,34,43H,23H2,1-2H3,(H,40,41,44,45)/t30-,32-,34-/m1/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe N4-Benzoyl-5'-O-DMTr-2',2'-difluoro-2'-deoxycytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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