Protected Nucleosides
N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-propargyl adenosine
Quick view. An adenosine derivative bearing N6-benzoyl, 5'-O-dimethoxytrityl and 2'-O-propargyl groups, CAS 171486-51-4. CAS 171486-51-4. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-propargyl adenosine is classified as protected nucleosides (Formula C41H37N5O7; molecular weight 711.77).
N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-propargyl adenosine is useful as a bioorthogonal handle for post-synthetic conjugation to fluorophores, affinity tags, surfaces, peptides or other functional payloads.
For N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-propargyl adenosine, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMTr-2'-O-propargyl-N6-benzoyladenosine
- N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-propargyladenosine
Useful catalog search terms
- CAS 171486-51-4
Physicochemical data
| Base protection | N6-benzoyl |
|---|---|
| 5' protection | dimethoxytrityl (DMTr) |
| 2'-O modification | propargyl |
| 3'-O state | free hydroxyl |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
These points describe N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-propargyl adenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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