2'-FANA Nucleosides
N6-Benzoyl-5'-O-DMTr-2'-fluoro-2'-deoxy-beta-D-arabinoadenosine
Quick view. Protected 2'-fluoro-2'-deoxy-beta-D-arabinoadenosine derivative bearing N6-benzoyl and 5'-O-DMTr groups. CAS 226415-08-3. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
N6-Benzoyl-5'-O-DMTr-2'-fluoro-2'-deoxy-beta-D-arabinoadenosine is classified as 2'-fana nucleosides (Formula C38H34FN5O6; molecular weight 675.72 g/mol).
N6-Benzoyl-5'-O-DMTr-2'-fluoro-2'-deoxy-beta-D-arabinoadenosine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For N6-Benzoyl-5'-O-DMTr-2'-fluoro-2'-deoxy-beta-D-arabinoadenosine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxy-beta-D-arabinoadenosine
Useful catalog search terms
- 226415-08-3
Physicochemical data
| Nucleoside | 2'-Deoxy-beta-D-arabinoadenosine |
|---|---|
| Modification | 2'-fluoro |
| Protection pattern | N6-benzoyl; 5'-O-DMTr |
| InChIKey | DDOOVEXTSRBCMU-MHHBZGPPSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe N6-Benzoyl-5'-O-DMTr-2'-fluoro-2'-deoxy-beta-D-arabinoadenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.