Modified Nucleosides
N6,N6-Dimethyl-2'-O-methyladenosine
Quick view. A stereodefined adenosine derivative bearing N6,N6-dimethyl and 2'-O-methyl modifications with free 3'- and 5'-hydroxyl groups, CAS 30891-53-3. CAS 30891-53-3. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
N6,N6-Dimethyl-2'-O-methyladenosine is classified as modified nucleosides (Formula C13H19N5O4; molecular weight 309.32 g/mol).
N6,N6-Dimethyl-2'-O-methyladenosine — Base- and sugar-methylated adenosine building block for modified nucleoside and RNA chemistry.
For N6,N6-Dimethyl-2'-O-methyladenosine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- N,N-Dimethyl-2'-O-methyladenosine
- N6,N6,2'-O-trimethyladenosine
- O2'-methyl-N6,N6-dimethyladenosine
Useful catalog search terms
- 30891-53-3
- PubChem CID 20722670
- IPRQAJTUSRLECG-QYVSTXNMSA-N
Physicochemical data
| PubChem CID | 20722670 |
|---|---|
| IUPAC name | (2R,3R,4R,5R)-5-[6-(dimethylamino)purin-9-yl]-2-(hydroxymethyl)-4-methoxyoxolan-3-ol |
| InChIKey | IPRQAJTUSRLECG-QYVSTXNMSA-N |
| InChI | InChI=1S/C13H19N5O4/c1-17(2)11-8-12(15-5-14-11)18(6-16-8)13-10(21-3)9(20)7(4-19)22-13/h5-7,9-10,13,19-20H,4H2,1-3H3/t7-,9-,10-,13-/m1/s1 |
| SMILES | CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)OC |
| Stereochemistry | (2R,3R,4R,5R) ribofuranose system |
| Nucleoside modification | N6,N6-dimethyl; 2'-O-methyl |
| Free hydroxyls | 3'-OH and 5'-OH |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Reference compound for chemical identity studies involving N6,N6-dimethyl-2'-O-methyladenosine.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe N6,N6-Dimethyl-2'-O-methyladenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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