Halogenated Nucleosides
2',3',5'-Tri-O-acetyl-5-(trifluoromethyl)uridine
Quick view. A tri-O-acetyl-protected uridine bearing a 5-trifluoromethyl base modification, identified by CAS 84500-34-5. CAS 84500-34-5. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2',3',5'-Tri-O-acetyl-5-(trifluoromethyl)uridine is classified as halogenated nucleosides (Formula C16H17F3N2O9; molecular weight 438.31).
2',3',5'-Tri-O-acetyl-5-(trifluoromethyl)uridine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 2',3',5'-Tri-O-acetyl-5-(trifluoromethyl)uridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 5-Trifluoromethyl-2',3',5'-tri-O-acetyluridine
Useful catalog search terms
- CAS 84500-34-5
- PubChem CID 127258195
Physicochemical data
| PubChem CID | 127258195 |
|---|---|
| InChIKey | RLCSLIOGASUNBC-NRWUCQMLSA-N |
| Nucleoside | uridine |
| Base modification | 5-trifluoromethyl |
| Hydroxyl protection | 2',3',5'-tri-O-acetyl |
| InChI | InChI=1S/C16H17F3N2O9/c1-6(22)27-5-10-11(28-7(2)23)12(29-8(3)24)14(30-10)21-4-9(16(17,18)19)13(25)20-15(21)26/h4,10-12,14H,5H2,1-3H3,(H,20,25,26)/t10-,11-,12+,14-/m1/s1 |
| SMILES | CC(=O)OC[C@@H]1[C@H]([C@@H]([C@@H](O1)N2C=C(C(=O)NC2=O)C(F)(F)F)OC(=O)C)OC(=O)C |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2',3',5'-Tri-O-acetyl-5-(trifluoromethyl)uridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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