Halogenated Nucleosides
2',3'-Dideoxy-3'-fluorocytidine
Quick view. A cytidine analog with fluorine at sugar C3' and no 2'- or 3'-hydroxyl group. CAS 51246-79-8. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2',3'-Dideoxy-3'-fluorocytidine is classified as 3'-fluoro-2',3'-dideoxy cytidine nucleoside (Formula C9H12FN3O3; molecular weight 229.21 g/mol).
2',3'-Dideoxy-3'-fluorocytidine can be evaluated in chain-termination, sequencing-control or polymerase-specific substrate studies.
For 2',3'-Dideoxy-3'-fluorocytidine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Useful catalog search terms
- 51246-79-8
- HNSUDSIHCJEYQG-SHYZEUOFSA-N
Physicochemical data
| PubChem CID | 451363 |
|---|---|
| IUPAC name | 4-amino-1-[(2R,4S,5R)-4-fluoro-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one |
| InChIKey | HNSUDSIHCJEYQG-SHYZEUOFSA-N |
| InChI | InChI=1S/C9H12FN3O3/c10-5-3-8(16-6(5)4-14)13-2-1-7(11)12-9(13)15/h1-2,5-6,8,14H,3-4H2,(H2,11,12,15)/t5-,6+,8+/m0/s1 |
| SMILES | C1[C@@H]([C@H](O[C@H]1N2C=CC(=NC2=O)N)CO)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2',3'-Dideoxy-3'-fluorocytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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