2'-F Nucleosides
2',5'-Dideoxy-2'-fluoro-5'-iodouridine
Quick view. Uridine derivative bearing a 2'-fluoro substituent and a 5'-iodomethyl group on a 2',5'-dideoxy sugar. CAS 211694-25-6. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2',5'-Dideoxy-2'-fluoro-5'-iodouridine is classified as 2'-f nucleosides (Formula C9H10FIN2O4; molecular weight 356.09 g/mol).
2',5'-Dideoxy-2'-fluoro-5'-iodouridine can be evaluated in chain-termination, sequencing-control or polymerase-specific substrate studies.
For 2',5'-Dideoxy-2'-fluoro-5'-iodouridine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- Uridine, 2',5'-dideoxy-2'-fluoro-5'-iodo-
Useful catalog search terms
- 211694-25-6
Physicochemical data
| Base scaffold | Uridine |
|---|---|
| Sugar modification | 2',5'-dideoxy |
| 2' substitution | Fluoro |
| 5'-substitution | Iodomethyl |
| InChIKey | QLNYKCHAXHDXHT-XVFCMESISA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2',5'-Dideoxy-2'-fluoro-5'-iodouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-F Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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