Modified Nucleosides
2',5'-Dideoxyuridine
Quick view. A stereodefined uridine derivative lacking the 2'-hydroxyl and terminal 5'-hydroxyl groups, CAS 35959-50-3. CAS 35959-50-3. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2',5'-Dideoxyuridine is classified as modified nucleosides (Formula C9H12N2O4; molecular weight 212.20 g/mol).
2',5'-Dideoxyuridine for modified-nucleoside chemistry and identity research.
For 2',5'-Dideoxyuridine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- Uridine, 2',5'-dideoxy-
Useful catalog search terms
- 35959-50-3
- C9H12N2O4
- FDCFKLBIAIKUKB-GKROBHDKSA-N
Physicochemical data
| Systematic name | 1-[(2R,4S,5R)-4-hydroxy-5-methyloxolan-2-yl]pyrimidine-2,4-dione |
|---|---|
| InChIKey | FDCFKLBIAIKUKB-GKROBHDKSA-N |
| InChI | InChI=1S/C9H12N2O4/c1-5-6(12)4-8(15-5)11-3-2-7(13)10-9(11)14/h2-3,5-6,8,12H,4H2,1H3,(H,10,13,14)/t5-,6+,8-/m1/s1 |
| SMILES | C[C@@H]1[C@H](C[C@@H](O1)N2C=CC(=O)NC2=O)O |
| Nucleoside modification | 2',5'-dideoxy |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 2',5'-Dideoxyuridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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