Modified Nucleosides
2'-Deoxy-2-thiouridine
Quick view. A 2'-deoxyuridine derivative in which the nucleobase C2 carbonyl oxygen is replaced by sulfur. CAS 35059-12-2. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2'-Deoxy-2-thiouridine is classified as 2'-deoxy-2-thio pyrimidine nucleoside (Formula C9H12N2O4S; molecular weight 244.27 g/mol).
2'-Deoxy-2-thiouridine is associated with uridine-containing substrates for U-position incorporation in RNA or modified RNA studies.
For 2'-Deoxy-2-thiouridine, confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- 2-Thiodeoxyuridine
- 2-Thio 2'-Deoxyuridine
Useful catalog search terms
- 35059-12-2
- QVBGIJMTWBYCDQ-SHYZEUOFSA-N
Physicochemical data
| PubChem CID | 3012251 |
|---|---|
| IUPAC name | 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-sulfanylidenepyrimidin-4-one |
| InChIKey | QVBGIJMTWBYCDQ-SHYZEUOFSA-N |
| InChI | InChI=1S/C9H12N2O4S/c12-4-6-5(13)3-8(15-6)11-2-1-7(14)10-9(11)16/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,16)/t5-,6+,8+/m0/s1 |
| SMILES | C1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=S)CO)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
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Product-relevant literature
The publications below discuss named chemistry or a structural feature represented by this product. They provide scientific context only and are not an OROGO lot specification or product-performance claim.
- Prebiotic phosphorylation of 2-thiouridine provides either nucleotides or DNA building blocks via photoreduction. (2019)
- Synthesis and photochemical behavior of the tetrazolo tautomer of 2-azido-4-pyrimidinone-2'-deoxyriboside. (2011)
- Enzymatic synthesis and phosphorolysis of 4(2)-thioxo- and 6(5)-azapyrimidine nucleosides by E. coli nucleoside phosphorylases. (2016)
- Desulfurization of 2-thiouracil nucleosides: conformational studies of 4-pyrimidinone nucleosides. (2011)
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