Halogenated Nucleosides
2-Fluoro-6-O-[2-(4-nitrophenyl)ethyl]inosine
Quick view. A fluorinated inosine derivative bearing fluorine at purine C2 and a 2-(4-nitrophenyl)ethyl group at O6, CAS 171284-49-4. CAS 171284-49-4. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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![Chemical structure of 2-Fluoro-6-O-[2-(4-nitrophenyl)ethyl]inosine](/structures/8c60c0978c7c74af.svg)
Product profile
2-Fluoro-6-O-[2-(4-nitrophenyl)ethyl]inosine is classified as halogenated nucleosides (Formula C18H18FN5O7; molecular weight 435.36).
2-Fluoro-6-O-[2-(4-nitrophenyl)ethyl]inosine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 2-Fluoro-6-O-[2-(4-nitrophenyl)ethyl]inosine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 2-Fluoro-O6-(p-nitrophenylethyl)inosine
- Inosine, 2-fluoro-6-O-[2-(4-nitrophenyl)ethyl]-
Useful catalog search terms
- CAS 171284-49-4
Physicochemical data
| Purine substitution | 2-fluoro |
|---|---|
| O-protecting group | 6-O-[2-(4-nitrophenyl)ethyl] (NPE) |
| Sugar form | ribofuranosyl inosine |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2-Fluoro-6-O-[2-(4-nitrophenyl)ethyl]inosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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