Halogenated Nucleosides
2'-O-Acetyl-5'-O-(p-toluoyl)-3'-deoxy-3'-fluoro-5-methoxyuridine
Quick view. Protected uridine derivative bearing 3'-fluoro and 5-methoxy modifications with 2'-O-acetyl and 5'-O-(p-toluoyl) groups. CAS 2072145-81-2. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2'-O-Acetyl-5'-O-(p-toluoyl)-3'-deoxy-3'-fluoro-5-methoxyuridine is classified as halogenated nucleosides (Formula C20H21FN2O8; molecular weight 436.39 g/mol).
2'-O-Acetyl-5'-O-(p-toluoyl)-3'-deoxy-3'-fluoro-5-methoxyuridine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 2'-O-Acetyl-5'-O-(p-toluoyl)-3'-deoxy-3'-fluoro-5-methoxyuridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 2'-O-Acetyl-5'-O-(p-toluoyl)-3'-deoxy-3'-fluoro-5-methoxyluridine
Useful catalog search terms
- 2072145-81-2
Physicochemical data
| Nucleoside | uridine |
|---|---|
| Substitution pattern | 3'-deoxy-3'-fluoro; 5-methoxy |
| Protection pattern | 2'-O-acetyl; 5'-O-(p-toluoyl) |
| InChIKey | RZJNSVNZZHSGMP-YFHUEUNASA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-O-Acetyl-5'-O-(p-toluoyl)-3'-deoxy-3'-fluoro-5-methoxyuridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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