2'-O-Me Nucleosides
2'-O-Methyl-N1-methylinosine
Quick view. An inosine nucleoside bearing 2'-O-methyl and N1-methyl substitutions for modified-nucleoside and nucleic-acid chemistry research. CAS 65150-69-8. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2'-O-Methyl-N1-methylinosine is classified as 2'-o-me nucleosides (Formula C12H16N4O5; molecular weight 296.28).
2'-O-Methyl-N1-methylinosine — 2'-O- and N1-methylated inosine building block for structure-specific modified-nucleoside and nucleic-acid chemistry research.
For 2'-O-Methyl-N1-methylinosine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 1,2'-O-Dimethylinosine
- Inosine, 1-methyl-2'-O-methyl-
- TNU0549
Useful catalog search terms
- CAS 65150-69-8
Physicochemical data
| InChIKey | JSRIPIORIMCGTG-WOUKDFQISA-N |
|---|---|
| SMILES | CO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(=O)n(C)cnc21 |
| Sugar modification | 2'-O-methyl |
| Base modification | N1-methyl |
| Chemical form | Unprotected inosine nucleoside |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Methyl-N1-methylinosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.