Amino-modified Nucleosides
3'-Azido-3'-deoxyadenosine
Quick view. An adenosine analogue in which the ribose 3'-hydroxyl is replaced by an azido group. CAS 58699-62-0. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
3'-Azido-3'-deoxyadenosine is classified as 3'-azido purine nucleoside (Formula C10H12N8O3; molecular weight 292.25 g/mol).
3'-Azido-3'-deoxyadenosine — Reported as the free-nucleoside input for dipolar-cycloaddition routes to 3'-triazolyl dinucleotides and in named 3'-azido RNA synthesis workflows.
For 3'-Azido-3'-deoxyadenosine, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- 3'-N3-Ado
- (2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-4-azido-5-(hydroxymethyl)tetrahydrofuran-3-ol
Useful catalog search terms
- 58699-62-0
- MFCD27921039
- HTWSTKVLFZRAPM-QYYRPYCUSA-N
Physicochemical data
| Exact mass | 292.10 g/mol |
|---|---|
| InChIKey | HTWSTKVLFZRAPM-QYYRPYCUSA-N |
| MDL number | MFCD27921039 |
| PubChem CID | 5273012 |
| InChI | InChI=1S/C10H12N8O3/c11-8-6-9(14-2-13-8)18(3-15-6)10-7(20)5(16-17-12)4(1-19)21-10/h2-5,7,10,19-20H,1H2,(H2,11,13,14)/t4-,5-,7-,10-/m1/s1 |
| SMILES | C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)N=[N+]=[N-])O)N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe 3'-Azido-3'-deoxyadenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-relevant literature
The publications below discuss named chemistry or a structural feature represented by this product. They provide scientific context only and are not an OROGO lot specification or product-performance claim.
Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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