Halogenated Nucleosides
3'-Deoxy-3'-fluoro-xylo-uridine
Quick view. A xylo-configured uridine derivative bearing 3'-deoxy-3'-fluoro substitution, CAS 129885-95-6. CAS 129885-95-6. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
3'-Deoxy-3'-fluoro-xylo-uridine is classified as halogenated nucleosides (Formula C9H11FN2O5; molecular weight 246.19).
3'-Deoxy-3'-fluoro-xylo-uridine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 3'-Deoxy-3'-fluoro-xylo-uridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 9-(3-deoxy-3-fluoro-D-xylofuranosyl)uracil
Useful catalog search terms
- CAS 129885-95-6
Physicochemical data
| Configuration | xylo |
|---|---|
| Modification | 3'-deoxy-3'-fluoro |
| PubChem CID | 14312485 |
| InChI | InChI=1S/C9H11FN2O5/c10-6-4(3-13)17-8(7(6)15)12-2-1-5(14)11-9(12)16/h1-2,4,6-8,13,15H,3H2,(H,11,14,16)/t4-,6+,7-,8-/m1/s1 |
| InChIKey | FVBOTRDLABQYMI-PXBUCIJWSA-N |
| SMILES | O=c1ccn([C@@H]2O[C@H](CO)[C@H](F)[C@H]2O)c(=O)[nH]1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 3'-Deoxy-3'-fluoro-xylo-uridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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