Modified Nucleosides
5-(Carboxy(hydroxy)methyl)uridine methyl ester
Quick view. A uridine nucleoside bearing a hydroxyacetate methyl ester substituent at base C5; side-chain stereochemistry is unspecified. CAS 945684-13-9. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
Request a quote Review request checklist
Product profile
5-(Carboxy(hydroxy)methyl)uridine methyl ester is classified as c5-substituted uridine methyl ester (Formula C12H16N2O9; molecular weight 332.26 g/mol).
5-(Carboxy(hydroxy)methyl)uridine methyl ester provides a reactive functional group for conjugation, immobilization or linker-extension studies.
For 5-(Carboxy(hydroxy)methyl)uridine methyl ester, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 5-(1-Hydroxy)(methoxy carbonyl)methyl uridine
- 5-Pyrimidineacetic acid, 1,2,3,4-tetrahydro-alpha-hydroxy-2,4-dioxo-1-beta-D-ribofuranosyl-, methyl ester
Useful catalog search terms
- 945684-13-9
- JNVLKTZUCGRYNN-LQGIRWEJSA-N
Physicochemical data
| PubChem CID | 146066 |
|---|---|
| IUPAC name | methyl 2-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4-dioxopyrimidin-5-yl]-2-hydroxyacetate |
| InChIKey | JNVLKTZUCGRYNN-LQGIRWEJSA-N |
| Stereochemistry | Ribofuranose stereochemistry defined; side-chain hydroxy stereocenter unspecified |
| InChI | InChI=1S/C12H16N2O9/c1-22-11(20)6(16)4-2-14(12(21)13-9(4)19)10-8(18)7(17)5(3-15)23-10/h2,5-8,10,15-18H,3H2,1H3,(H,13,19,21)/t5-,6?,7-,8-,10-/m1/s1 |
| SMILES | COC(=O)C(C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe 5-(Carboxy(hydroxy)methyl)uridine methyl ester or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
(S)-cEt-rA
Modified Nucleosides · CAS: 1197033-34-3
OR-OP-0069S-Adenosyl-L-methionine (SAM)
Modified Nucleosides · CAS: 485-80-3
OR-MN-01875-(Carboxyhydroxymethyl)uridine
Modified Nucleosides · CAS: 934743-11-0
OR-MN-0719(R)-N6-(2,3-Dihydro-1H-inden-1-yl)adenosine
Modified Nucleosides · CAS: 96392-15-3
OR-MN-01972,2'-Cyclocytidine hydrochloride
Modified Nucleosides · CAS: 10212-25-6
OR-MN-0199N3-Allyluridine
Modified Nucleosides · CAS: 103951-13-9
Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Request a quote Review request checklist
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.