LNA Locked Nucleosides
5'-Azido-5'-deoxy-2'-O,4'-C-methyleneuridine
Quick view. Locked uridine derivative bearing a 5'-azido group and a 2'-O,4'-C methylene bridge. CAS 2305415-75-0. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-Azido-5'-deoxy-2'-O,4'-C-methyleneuridine is classified as lna locked nucleosides (Formula C10H11N5O5; molecular weight 281.23 g/mol).
5'-Azido-5'-deoxy-2'-O,4'-C-methyleneuridine is useful as a bioorthogonal handle for post-synthetic conjugation to fluorophores, affinity tags, surfaces, peptides or other functional payloads.
For 5'-Azido-5'-deoxy-2'-O,4'-C-methyleneuridine, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Useful catalog search terms
- 2305415-75-0
Physicochemical data
| Nucleoside | Locked uridine |
|---|---|
| Substitution pattern | 5'-azido; 5'-deoxy; 2'-O,4'-C methylene bridge |
| InChIKey | PFXWOPNWYGPHBA-JIOCBJNQSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe 5'-Azido-5'-deoxy-2'-O,4'-C-methyleneuridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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