Halogenated Nucleosides
5'-Deoxy-5-fluoro-N4-(isopentyloxycarbonyl)cytidine
Quick view. A protected, fluorinated cytidine building block for structure-specific nucleoside synthesis and capecitabine-related impurity research. CAS 162204-30-0. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-Deoxy-5-fluoro-N4-(isopentyloxycarbonyl)cytidine is classified as halogenated nucleosides (Formula C15H22FN3O6; molecular weight 359.35).
5'-Deoxy-5-fluoro-N4-(isopentyloxycarbonyl)cytidine — Protected fluorinated cytidine building block for structure-specific nucleoside synthesis and capecitabine-related impurity research.
For 5'-Deoxy-5-fluoro-N4-(isopentyloxycarbonyl)cytidine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 5'-Deoxy-5-fluoro-N-[(3-methylbutoxy)carbonyl]cytidine
- Capecitabine EP Impurity E
Useful catalog search terms
- CAS 162204-30-0
- 5-deoxy 5-fluoro isopentyloxycarbonyl cytidine
Physicochemical data
| Sugar modification | 5'-deoxy |
|---|---|
| Nucleobase modification | 5-fluoro; N4-(3-methylbutoxycarbonyl) |
| InChI | InChI=1S/C15H22FN3O6/c1-7(2)4-5-24-15(23)18-12-9(16)6-19(14(22)17-12)13-11(21)10(20)8(3)25-13/h6-8,10-11,13,20-21H,4-5H2,1-3H3,(H,17,18,22,23)/t8-,10-,11-,13-/m1/s1 |
| InChIKey | PPVCPOIDSSQXMR-UORFTKCHSA-N |
| SMILES | C[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=C(C(=NC2=O)NC(=O)OCCC(C)C)F)O)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5'-Deoxy-5-fluoro-N4-(isopentyloxycarbonyl)cytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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