Halogenated Nucleosides
5'-Deoxy-5'-iodo-2'-O-methyluridine
Quick view. A 2'-O-methyluridine derivative bearing a 5'-deoxy-5'-iodo substitution, CAS 194034-84-9. CAS 194034-84-9. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-Deoxy-5'-iodo-2'-O-methyluridine is classified as halogenated nucleosides (Formula C10H13IN2O5; molecular weight 368.13).
5'-Deoxy-5'-iodo-2'-O-methyluridine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 5'-Deoxy-5'-iodo-2'-O-methyluridine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- Uridine, 5'-deoxy-5'-iodo-2'-O-methyl-
- MFCD30718528
- GL102023
- CB23334290
Useful catalog search terms
- CAS 194034-84-9
- C10H13IN2O5
- CFYDJUFIBSHGPJ-ZOQUXTDFSA-N
Physicochemical data
| Nucleobase | Uracil |
|---|---|
| Sugar modification | 2'-O-Methyl |
| 5'-substitution | 5'-Deoxy-5'-iodo |
| Free hydroxyl | 3'-OH |
| Stereochemistry | Four assigned ribofuranosyl stereocenters |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-Deoxy-5'-iodo-2'-O-methyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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