Intermediates
5-Fluorouracil-1-yl acetic acid methyl ester
Quick view. A 5-fluorouracil derivative bearing a methyl acetate substituent at the pyrimidine N1 position. CAS 56059-28-0. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5-Fluorouracil-1-yl acetic acid methyl ester is classified as 5-fluorouracil n1-acetate methyl ester (Formula C7H7FN2O4; molecular weight 202.14 g/mol).
5-Fluorouracil-1-yl acetic acid methyl ester is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 5-Fluorouracil-1-yl acetic acid methyl ester, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- Methyl 2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetate
Useful catalog search terms
- 56059-28-0
- ATGWGHLJNFEABD-UHFFFAOYSA-N
Physicochemical data
| InChIKey | ATGWGHLJNFEABD-UHFFFAOYSA-N |
|---|---|
| InChI | InChI=1S/C7H7FN2O4/c1-14-5(11)3-10-2-4(8)6(12)9-7(10)13/h2H,3H2,1H3,(H,9,12,13) |
| SMILES | COC(=O)CN1C=C(C(=O)NC1=O)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-Fluorouracil-1-yl acetic acid methyl ester or its named chemical feature. Broader product-family guidance is maintained on the category page.
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