2'-O-Me Nucleosides
5-(Furan-2-yl)-2'-O-methyl-5'-O-DMTr-uridine
Quick view. Protected 2'-O-methyl uridine derivative bearing a 5-(furan-2-yl) substituent and a 5'-O-dimethoxytrityl group. CAS 2095417-47-1. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5-(Furan-2-yl)-2'-O-methyl-5'-O-DMTr-uridine is classified as 2'-o-me nucleosides (Formula C35H34N2O9; molecular weight 626.66 g/mol).
5-(Furan-2-yl)-2'-O-methyl-5'-O-DMTr-uridine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 5-(Furan-2-yl)-2'-O-methyl-5'-O-DMTr-uridine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 5-Furan-2-yl-2'-O-methyl-5'-O-DMT-uridine
Useful catalog search terms
- 2095417-47-1
Physicochemical data
| Base scaffold | Uridine |
|---|---|
| Base modification | 5-(furan-2-yl) |
| Sugar modification | 2'-O-methyl |
| 5' protection | O-DMTr |
| InChIKey | HTMVCWPFTLMWRP-WTGZKXAYSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5-(Furan-2-yl)-2'-O-methyl-5'-O-DMTr-uridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.