2'-O-Me Phosphoramidites
5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-N6-methyladenosine 3'-CED phosphoramidite
Quick view. N6-methyl-2'-O-methyladenosine 3'-CED phosphoramidite bearing 5'-O-dimethoxytrityl protection. CAS 2348385-04-4. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-N6-methyladenosine 3'-CED phosphoramidite is classified as 2'-o-me phosphoramidites (Formula C42H52N7O7P; molecular weight 797.90 g/mol).
5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-N6-methyladenosine 3'-CED phosphoramidite supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-N6-methyladenosine 3'-CED phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Useful catalog search terms
- 2348385-04-4
Physicochemical data
| PubChem CID | 167312661 |
|---|---|
| Nucleoside | Adenosine |
| Substitution pattern | N6-methyl; 2'-O-methyl; 3'-CED phosphoramidite; 5'-O-DMTr |
| Stereochemical scope | Sugar stereochemistry defined; phosphorus configuration unspecified |
| IUPAC name | 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxy-5-[6-(methylamino)purin-9-yl]oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile |
| InChIKey | XXRTXDUOPCNYDH-DJADKNTFSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-N6-methyladenosine 3'-CED phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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