Protected Nucleosides
5'-O-DMTr-3'-O-TBDMS-N1-methylpseudouridine
Quick view. A protected N1-methylpseudouridine intermediate bearing 5'-O-DMTr and 3'-O-TBDMS groups, identified by CAS 875302-43-5. CAS 875302-43-5. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-O-DMTr-3'-O-TBDMS-N1-methylpseudouridine is classified as protected nucleosides (Formula C37H46N2O8Si; molecular weight 674.86).
5'-O-DMTr-3'-O-TBDMS-N1-methylpseudouridine is relevant to modified RNA, mRNA optimization, epitranscriptomic standards or immune-recognition studies depending on the format supplied.
For 5'-O-DMTr-3'-O-TBDMS-N1-methylpseudouridine, modification benefits are context-dependent; transcript length, substitution level, enzyme system and analytical purity can change the observed outcome.
Names and search terms
Confirmed or normalized name variants
- 5'-O-(4,4'-Dimethoxytrityl)-3'-O-tert-butyldimethylsilyl-N1-methylpseudouridine
- 5'-DMT-3'-O-TBDMS-N1-Me-Pseudouridine
Useful catalog search terms
- CAS 875302-43-5
Physicochemical data
| Nucleoside | N1-methylpseudouridine |
|---|---|
| Sugar protection | 5'-O-DMTr and 3'-O-TBDMS |
| Free hydroxyl | 2'-OH |
| PubChem CID | 67259754 |
| InChI | InChI=1S/C37H46N2O8Si/c1-36(2,3)48(7,8)47-33-30(46-32(31(33)40)29-22-39(4)35(42)38-34(29)41)23-45-37(24-12-10-9-11-13-24,25-14-18-27(43-5)19-15-25)26-16-20-28(44-6)21-17-26/h9-22,30-33,40H,23H2,1-8H3,(H,38,41,42)/t30-,31+,32+,33-/m1/s1 |
| InChIKey | DOMAILDWCRIGEQ-JDIHBLRXSA-N |
| SMILES | CC(C)(C)[Si](C)(C)O[C@@H]1[C@H](O[C@H]([C@@H]1O)C2=CN(C(=O)NC2=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Base modifications can tune RNA stability, translation behavior, duplex properties or analytical discrimination versus native bases.
Method limitations
- Modification benefits are context-dependent; transcript length, substitution level, enzyme system and analytical purity can change the observed outcome.
These points describe 5'-O-DMTr-3'-O-TBDMS-N1-methylpseudouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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