DMTr-protected Nucleosides
5'-O-DMTr-2'-O-Me-rC(Bz)
Quick view. N4-benzoyl-protected cytidine bearing a 5'-O-DMTr group, a 2'-O-methyl substituent and a free 3'-hydroxyl. CAS 110764-74-4. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-O-DMTr-2'-O-Me-rC(Bz) is classified as dmtr-protected nucleosides (Formula C38H37N3O8; molecular weight 663.72).
5'-O-DMTr-2'-O-Me-rC(Bz) supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 5'-O-DMTr-2'-O-Me-rC(Bz), excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- N4-Benzoyl-5'-O-DMTr-2'-O-methylcytidine
- N4-Bz-DMT-2'-O-Me-C
Useful catalog search terms
- CAS 110764-74-4
Physicochemical data
| Nucleoside | Cytidine |
|---|---|
| Base protection | N4-benzoyl |
| Hydroxyl protection | 5'-O-DMTr |
| Sugar modification | 2'-O-methyl |
| Hydroxyl state | 3' hydroxyl group unprotected |
| InChI | InChI=1S/C38H37N3O8/c1-45-29-18-14-27(15-19-29)38(26-12-8-5-9-13-26,28-16-20-30(46-2)21-17-28)48-24-31-33(42)34(47-3)36(49-31)41-23-22-32(40-37(41)44)39-35(43)25-10-6-4-7-11-25/h4-23,31,33-34,36,42H,24H2,1-3H3,(H,39,40,43,44)/t31-,33-,34-,36-/m1/s1 |
| InChIKey | WXJKGOQQYUVNQW-YDXJMRNDSA-N |
| SMILES | CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-O-DMTr-2'-O-Me-rC(Bz) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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