ddNTPs
5-Propargylamino-ddUTP
Quick view. An amino-functionalized dideoxyuridine triphosphate for dye-nucleotide conjugate preparation, nucleic-acid labeling, and sequence-analysis research. CAS 114748-59-3. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Identifier context
These notes preserve the current catalog identifiers while making their review boundary explicit.
This CAS number is shared by multiple OROGO catalog records. Confirm the exact salt, counterion, concentration and supplied form when requesting a quote.
Product profile
5-Propargylamino-ddUTP is classified as ddntps (Formula C12H18N3O13P3; molecular weight 505.20).
5-Propargylamino-ddUTP — Cyanine dye-nucleotide conjugate preparation
For 5-Propargylamino-ddUTP, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Useful catalog search terms
- 114748-59-3
Physicochemical data
| Nucleotide type | Modified 2',3'-dideoxyuridine triphosphate |
|---|---|
| Functional handle | Propargylamine |
| Storage temperature | -20 C for powder format |
| PubChem CID | 11071202 |
| InChIKey | HOYCULDIPQRPFI-VHSXEESVSA-N |
| InChI | InChI=1S/C12H18N3O13P3/c13-5-1-2-8-6-15(12(17)14-11(8)16)10-4-3-9(26-10)7-25-30(21,22)28-31(23,24)27-29(18,19)20/h6,9-10H,3-5,7,13H2,(H,21,22)(H,23,24)(H,14,16,17)(H2,18,19,20)/t9-,10+/m0/s1 |
| SMILES | NCC#Cc1cn([C@H]2CC[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O |
| CAS review status | This CAS number is shared by multiple OROGO catalog records. Confirm the exact salt, counterion, concentration and supplied form when requesting a quote. |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Nucleic-acid labeling and sequence-analysis research
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 5-Propargylamino-ddUTP or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-relevant literature
The publications below discuss named chemistry or a structural feature represented by this product. They provide scientific context only and are not an OROGO lot specification or product-performance claim.
Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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