2'-O-Me Phosphoramidites
5'-O-DMTr-2'-O-Me-N6-benzoyl-N6-methyladenosine-3'-CE-Phosphoramidite
Quick view. A protected N6-benzoyl-N6-methyladenosine CE phosphoramidite bearing 5'-O-DMTr and 2'-O-methyl substitution for oligonucleotide synthesis research. CAS 2659239-32-2. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-O-DMTr-2'-O-Me-N6-benzoyl-N6-methyladenosine-3'-CE-Phosphoramidite is classified as 2'-o-me phosphoramidites (Formula C49H56N7O8P; molecular weight 902.00).
5'-O-DMTr-2'-O-Me-N6-benzoyl-N6-methyladenosine-3'-CE-Phosphoramidite — Protected modified adenosine phosphoramidite building block for oligonucleotide synthesis research.
For 5'-O-DMTr-2'-O-Me-N6-benzoyl-N6-methyladenosine-3'-CE-Phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- DMTr-2'-O-Me-N6-Me-rA(Bz)-3'-CE-Phosphoramidite
- DMT-2'-OMe-dA(bz) phosphoramidite
Useful catalog search terms
- CAS 2659239-32-2
- BECWGTDZHSWGIY-FVPMUMJWSA-N
Physicochemical data
| InChIKey | BECWGTDZHSWGIY-FVPMUMJWSA-N |
|---|---|
| Base modification | N6-methyl |
| Base protection | N6-benzoyl |
| Ribose modification | 2'-O-methyl |
| 5' protection | 5'-O-DMTr |
| Coupling group | 3'-CE phosphoramidite |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-O-DMTr-2'-O-Me-N6-benzoyl-N6-methyladenosine-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.