2'-O-Me Phosphoramidites
DMTr-2'-O-Me-rC(Bz)-3'-CE Phosphoramidite
Quick view. DMTr-2'-O-Me-rC(Bz)-3'-CE Phosphoramidite is an N4-benzoyl-protected 2'-O-methyl cytidine building block for research-use oligonucleotide synthesis. CAS 110764-78-8. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
DMTr-2'-O-Me-rC(Bz)-3'-CE Phosphoramidite is classified as protected 2'-o-methyl cytidine phosphoramidite (Formula C47H54N5O9P; molecular weight 863.90).
DMTr-2'-O-Me-rC(Bz)-3'-CE Phosphoramidite — N4-benzoyl-protected 2'-O-methyl cytidine phosphoramidite building block for research-use oligonucleotide synthesis.
For DMTr-2'-O-Me-rC(Bz)-3'-CE Phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 2'-OMe-Bz-C Phosphoramidite
- DMT-2'-O-methyl-rC(Bz) Phosphoramidite
- N4-Bz-5'-O-DMTr-2'-O-methylcytidine-3'-CED Phosphoramidite
Useful catalog search terms
- 110764-78-8
- PubChem 13872225
- C47H54N5O9P
Physicochemical data
| Base protection | N4-benzoyl |
|---|---|
| Ribose modification | 2'-O-methyl |
| Synthesis format | 5'-DMTr and 3'-2-cyanoethyl N,N-diisopropyl phosphoramidite |
| InChIKey | JFFSFQRVIPPCBC-VKBHKTMGSA-N |
| InChI | InChI=1S/C47H54N5O9P/c1-32(2)52(33(3)4)62(59-30-14-28-48)61-42-40(60-45(43(42)57-7)51-29-27-41(50-46(51)54)49-44(53)34-15-10-8-11-16-34)31-58-47(35-17-12-9-13-18-35,36-19-23-38(55-5)24-20-36)37-21-25-39(56-6)26-22-37/h8-13,15-27,29,32-33,40,42-43,45H,14,30-31H2,1-7H3,(H,49,50,53,54)/t40-,42-,43-,45-,62?/m1/s1 |
| SMILES | COc1ccc(C(OC[C@H]2O[C@@H](n3ccc(=NC(=O)c4ccccc4)nc3O)[C@H](OC)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe DMTr-2'-O-Me-rC(Bz)-3'-CE Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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