RNA (2'-O-TBDMS) Phosphoramidites
5'-O-DMTr-2'-O-TBDMS-5-methyl-beta-D-uridine-3'-CE phosphoramidite
Quick view. A beta-D-5-methyluridine building block bearing 5'-O-DMTr and 2'-O-TBDMS protection with a 3'-cyanoethyl N,N-diisopropylphosphoramidite functionality. CAS 159639-78-8. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-O-DMTr-2'-O-TBDMS-5-methyl-beta-D-uridine-3'-CE phosphoramidite is classified as rna (2'-o-tbdms) phosphoramidites (Formula C46H63N4O9PSi; molecular weight 875.09).
5'-O-DMTr-2'-O-TBDMS-5-methyl-beta-D-uridine-3'-CE phosphoramidite — Identity-defined 2'-O-TBDMS-5-methyluridine phosphoramidite for research workflows involving solid-phase oligonucleotide synthesis.
For 5'-O-DMTr-2'-O-TBDMS-5-methyl-beta-D-uridine-3'-CE phosphoramidite, confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMTr-2'-O-TBDMS-5-Me-U-3'-CE phosphoramidite
- DMT-2'-O-TBDMS-5-Me-rU phosphoramidite
- 2'-O-TBDMS-rT phosphoramidite
Useful catalog search terms
- CAS 159639-78-8
Physicochemical data
| InChIKey | KYRSLFQMFXXGLW-IEXCOMMKSA-N |
|---|---|
| Nucleoside | 5-Methyl-beta-D-uridine |
| Ribofuranosyl stereochemistry | (2R,3R,4R,5R) |
| Base protection | None |
| 5' protection | DMTr |
| 2' protection | TBDMS |
| 3'-Coupling group | 2-Cyanoethyl N,N-diisopropylphosphoramidite |
| PubChem CID | 138376017 |
| InChI | InChI=1S/C46H63N4O9PSi/c1-31(2)50(32(3)4)60(56-28-16-27-47)58-40-39(57-43(41(40)59-61(11,12)45(6,7)8)49-29-33(5)42(51)48-44(49)52)30-55-46(34-17-14-13-15-18-34,35-19-23-37(53-9)24-20-35)36-21-25-38(54-10)26-22-36/h13-15,17-26,29,31-32,39-41,43H,16,28,30H2,1-12H3,(H,48,51,52)/t39-,40-,41-,43-,60?/m1/s1 |
| SMILES | COc1ccc(C(OC[C@H]2O[C@@H](n3cc(C)c(=O)[nH]c3=O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
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Product-family literature
These publications provide peer-reviewed context for the RNA (2'-O-TBDMS) Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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