L-RNA Phosphoramidites
N2-Isobutyryl-5'-O-DMTr-2'-O-TBDMS-beta-L-guanosine-3'-CE phosphoramidite
Quick view. A beta-L-guanosine building block bearing N2-isobutyryl, 5'-O-DMTr, and 2'-O-TBDMS protection with a 3'-cyanoethyl N,N-diisopropylphosphoramidite functionality. CAS 679809-76-8. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
N2-Isobutyryl-5'-O-DMTr-2'-O-TBDMS-beta-L-guanosine-3'-CE phosphoramidite is classified as l-rna phosphoramidites (Formula C50H68N7O9PSi; molecular weight 970.19).
N2-Isobutyryl-5'-O-DMTr-2'-O-TBDMS-beta-L-guanosine-3'-CE phosphoramidite — Identity-defined L-rG(iBu) phosphoramidite for research workflows involving solid-phase oligonucleotide synthesis.
For N2-Isobutyryl-5'-O-DMTr-2'-O-TBDMS-beta-L-guanosine-3'-CE phosphoramidite, confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- L-rG(iBu) phosphoramidite
- 5'-O-DMTr-2'-O-TBDMS-L-G(iBu)-3'-CE phosphoramidite
- DMT-2'-O-TBDMS-L-rG(iBu) phosphoramidite
Useful catalog search terms
- CAS 679809-76-8
Physicochemical data
| InChIKey | PGJKESPHANLWME-ZEXYNXKFSA-N |
|---|---|
| Nucleoside | beta-L-Guanosine |
| Ribofuranosyl stereochemistry | (2S,3S,4S,5S) |
| Base protection | N2-Isobutyryl |
| 5' protection | DMTr |
| 2' protection | TBDMS |
| 3'-Coupling group | 2-Cyanoethyl N,N-diisopropylphosphoramidite |
| PubChem CID | 172909778 |
| InChI | InChI=1S/C50H68N7O9PSi/c1-32(2)45(58)54-48-53-44-41(46(59)55-48)52-31-56(44)47-43(66-68(12,13)49(7,8)9)42(65-67(63-29-17-28-51)57(33(3)4)34(5)6)40(64-47)30-62-50(35-18-15-14-16-19-35,36-20-24-38(60-10)25-21-36)37-22-26-39(61-11)27-23-37/h14-16,18-27,31-34,40,42-43,47H,17,29-30H2,1-13H3,(H2,53,54,55,58,59)/t40-,42-,43-,47-,67?/m0/s1 |
| SMILES | COc1ccc(C(OC[C@@H]2O[C@H](n3cnc4c(=O)[nH]c(NC(=O)C(C)C)nc43)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H]2OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
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Product-family literature
These publications provide peer-reviewed context for the L-RNA Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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