Other Phosphoramidites
[1-N-(4,4'-Dimethoxytrityl)-biotinyl-6-aminohexyl]-2-cyanoethyl-(N,N-diisopropyl)-phosphoramidite
Quick view. 5'-Biotin Phosphoramidite is a protected biotin-labeling reagent for oligonucleotide synthesis. CAS 135137-87-0. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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![Chemical structure of [1-N-(4,4'-Dimethoxytrityl)-biotinyl-6-aminohexyl]-2-cyanoethyl-(N,N-diisopropyl)-phosphoramidite](/structures/9b1c47ba3d422557.svg)
Product profile
[1-N-(4,4'-Dimethoxytrityl)-biotinyl-6-aminohexyl]-2-cyanoethyl-(N,N-diisopropyl)-phosphoramidite is classified as other phosphoramidites (Formula C46H64N5O6PS; molecular weight 846.10).
[1-N-(4,4'-Dimethoxytrityl)-biotinyl-6-aminohexyl]-2-cyanoethyl-(N,N-diisopropyl)-phosphoramidite — Phosphoramidite reagent for introducing a biotin label at the 5' terminus of an oligonucleotide during solid-phase synthesis.
For [1-N-(4,4'-Dimethoxytrityl)-biotinyl-6-aminohexyl]-2-cyanoethyl-(N,N-diisopropyl)-phosphoramidite, affinity tags can introduce steric effects; spacer length, label position and enzymatic incorporation efficiency should be verified.
Names and search terms
Confirmed or normalized name variants
- 5'-Biotin Phosphoramidite
- 5'-Biotin CE Phosphoramidite
- DMT-Biotin-C6 Phosphoramidite
- Biotin Amidite
Useful catalog search terms
- DMT-Biotin-C6 Amidite
- CAS 135137-87-0
- PubChem CID 91668436
Physicochemical data
| PubChem CID | 91668436 |
|---|---|
| InChIKey | RBXYKQBFPLXSJS-RYQQVEDISA-N |
| Storage temperature | -18 C |
| Label | Biotin |
| Reactive group | Cyanoethyl N,N-diisopropyl phosphoramidite |
| InChI | InChI=1S/C46H64N5O6PS/c1-34(2)51(35(3)4)58(57-32-16-29-47)56-31-15-8-7-14-30-48-43(52)20-13-12-19-42-44-41(33-59-42)50(45(53)49-44)46(36-17-10-9-11-18-36,37-21-25-39(54-5)26-22-37)38-23-27-40(55-6)28-24-38/h9-11,17-18,21-28,34-35,41-42,44H,7-8,12-16,19-20,30-33H2,1-6H3,(H,48,52)(H,49,53)/t41-,42-,44-,58?/m0/s1 |
| SMILES | CC(C)N(C(C)C)P(OCCCCCCNC(=O)CCCC[C@H]1[C@@H]2[C@H](CS1)N(C(=O)N2)C(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OCCC#N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Biotin labels provide strong downstream detection or enrichment options without radioactive labeling.
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Affinity tags can introduce steric effects; spacer length, label position and enzymatic incorporation efficiency should be verified.
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe [1-N-(4,4'-Dimethoxytrityl)-biotinyl-6-aminohexyl]-2-cyanoethyl-(N,N-diisopropyl)-phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-relevant literature
The publications below discuss named chemistry or a structural feature represented by this product. They provide scientific context only and are not an OROGO lot specification or product-performance claim.
Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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