Protected Nucleosides
N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-methoxyethyl)guanosine
Quick view. Guanosine derivative bearing N2-isobutyryl and 5'-O-dimethoxytrityl protection plus a 3'-O-(2-methoxyethyl) substituent, with a free 2'-hydroxyl group. CAS 256224-05-2. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-methoxyethyl)guanosine is classified as protected nucleosides (Formula C38H43N5O9; molecular weight 713.79 g/mol).
N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-methoxyethyl)guanosine is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-methoxyethyl)guanosine, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- N2-iso-Butyroyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(methoxyethyl)guanosine
Useful catalog search terms
- 256224-05-2
Physicochemical data
| Systematic name | N-[9-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-hydroxy-4-(2-methoxyethoxy)oxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide |
|---|---|
| Chemical form | Neutral N2-isobutyryl, 5'-O-DMTr-protected, 3'-O-MOE-modified guanosine |
| Structural scope | N2-isobutyryl, 5'-O-DMTr and 3'-O-(2-methoxyethyl) substitution with a free 2'-hydroxyl |
| Stereochemical scope | Four defined ribose stereocenters |
| InChIKey | GORMIDFTGJPHPL-BEGXHNNXSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-methoxyethyl)guanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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