Halogenated Nucleosides
N6-Benzoyl-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-fluoroadenosine
Quick view. A protected adenosine intermediate bearing N6-benzoyl, 3'-deoxy-3'-fluoro and 5'-O-DMTr substitution for structure-specific synthesis research. CAS 170871-87-1. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
N6-Benzoyl-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-fluoroadenosine is classified as halogenated nucleosides (Formula C38H34FN5O6; molecular weight 675.72).
N6-Benzoyl-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-fluoroadenosine — Protected 3'-fluoro-3'-deoxyadenosine intermediate for structure-specific modified-nucleoside and nucleotide synthesis research.
For N6-Benzoyl-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-fluoroadenosine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- N6-Benzoyl-3'-deoxy-5'-O-DMTr-3'-fluoroadenosine
- Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-deoxy-3'-fluoro-
Useful catalog search terms
- CAS 170871-87-1
- N6-benzoyl 3-fluoro DMTr adenosine
Physicochemical data
| Base protection | N6-Benzoyl |
|---|---|
| Sugar modification | 3'-Deoxy-3'-fluoro |
| 5' protection | 4,4'-Dimethoxytrityl (DMTr) |
| Free hydroxyl | 2'-OH |
| PubChem CID | 129081131 |
| InChI | InChI=1S/C38H34FN5O6/c1-47-28-17-13-26(14-18-28)38(25-11-7-4-8-12-25,27-15-19-29(48-2)20-16-27)49-21-30-31(39)33(45)37(50-30)44-23-42-32-34(40-22-41-35(32)44)43-36(46)24-9-5-3-6-10-24/h3-20,22-23,30-31,33,37,45H,21H2,1-2H3,(H,40,41,43,46)/t30-,31-,33-,37-/m1/s1 |
| InChIKey | TVVPSEDSHAQKKZ-VYUOYPLNSA-N |
| SMILES | COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OC[C@@H]4[C@H]([C@H]([C@@H](O4)N5C=NC6=C(N=CN=C65)NC(=O)C7=CC=CC=C7)O)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe N6-Benzoyl-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-fluoroadenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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