Thio Phosphoramidites
5'-DMT-2'-OMe-A(Bz)-3'-PS-Phosphoramidite
Quick view. 5'-DMT-2'-OMe-A(Bz)-3'-PS-Phosphoramidite is an N6-benzoyl-protected 2'-O-methyl adenosine thiophosphoramidite for research-use oligonucleotide synthesis. CAS N/A. Catalog target purity: HPLC ≥90%. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-DMT-2'-OMe-A(Bz)-3'-PS-Phosphoramidite is classified as n6-benzoyl-protected 2'-o-methyl adenosine thiophosphoramidite (Formula C52H53N6O8PS2; molecular weight 985.12).
5'-DMT-2'-OMe-A(Bz)-3'-PS-Phosphoramidite — Protected 2'-O-methyl adenosine thiophosphoramidite building block for research-use solid-phase oligonucleotide synthesis.
For 5'-DMT-2'-OMe-A(Bz)-3'-PS-Phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 2'-OMe-rA(Bz)-3'-PS-Phosphoramidite
Useful catalog search terms
- HR-00216001
- C52H53N6O8PS2
- Thio Phosphoramidites
Physicochemical data
| Key structural motifs | N6-benzoyl adenine, 5'-DMT protection, 2'-O-methyl ribose, and a 3'-thiophosphoramidite bearing S-(2-benzoylthioethyl) and pyrrolidino substituents |
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Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-DMT-2'-OMe-A(Bz)-3'-PS-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Thio Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.