3'-O-Me Nucleosides
3'-O-Methylguanosine
Quick view. 3'-O-Methylguanosine is a ribose-methylated guanosine derivative for research-use modified-nucleoside chemistry. CAS 10300-27-3. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
3'-O-Methylguanosine is classified as 3'-o-methyl ribonucleoside (Formula C11H15N5O5; molecular weight 297.27).
3'-O-Methylguanosine — 3'-O-methylated guanosine for research-use modified-nucleoside chemistry.
For 3'-O-Methylguanosine, the 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
Names and search terms
Confirmed or normalized name variants
- 3'-O-Me-rG
- 3'-OMe-G
- Guanosine, 3'-O-methyl-
Useful catalog search terms
- CAS 10300-27-3
Physicochemical data
| PubChem CID | 135742509 |
|---|---|
| InChIKey | UYARPHAXAJAZLU-KQYNXXCUSA-N |
| Modification | Methyl ether at the ribose 3'-oxygen |
| InChI | InChI=1S/C11H15N5O5/c1-20-7-4(2-17)21-10(6(7)18)16-3-13-5-8(16)14-11(12)15-9(5)19/h3-4,6-7,10,17-18H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,7-,10-/m1/s1 |
| SMILES | CO[C@@H]1[C@H](O[C@H]([C@@H]1O)N2C=NC3=C2NC(=NC3=O)N)CO |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
Method limitations
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
These points describe 3'-O-Methylguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 3'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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