Cap Analogs
m7(3'-OMeG)(5')vppp(5')(2'-OMeA)pU ammonium salt
Quick view. A modified trinucleotide cap analog in ammonium form for in-vitro nucleotide and RNA-synthesis research. CAS 3056979-94-0 and the listed composition refer to the inner-salt identity. CAS 3056979-94-0. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
m7(3'-OMeG)(5')vppp(5')(2'-OMeA)pU ammonium salt is classified as cap analogs.
m7(3'-OMeG)(5')vppp(5')(2'-OMeA)pU ammonium salt — Modified nucleotide material for in-vitro nucleotide and RNA-synthesis research.
For m7(3'-OMeG)(5')vppp(5')(2'-OMeA)pU ammonium salt, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- CAP m7(3'-OMeG)(5')vppp(5')(2'-OMeA)pU Ammonium Salt
- m7(3'-OMeG)vppp(2'-OMeA)pU
- CAP1812
- TNU1838
Useful catalog search terms
- CAP m7(3'-OMeG)(5')vppp(5')(2'-OMeA)pU
- CAS 3056979-94-0
Physicochemical data
| Related CAS | 3056979-94-0 (inner salt) |
|---|---|
| Counterion form | Ammonium product; stoichiometry unspecified |
| Nucleotide shorthand | m7(3'-OMeG)(5')vppp(5')(2'-OMeA)pU |
| Inner-salt molecular formula | C33H44N12O24P4 |
| Formula basis | Inner-salt form |
| Inner-salt molecular weight | 1116.67 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
- Cap analog selection can influence capping efficiency, orientation and downstream translation-related performance.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
- Capping outcome depends on polymerase system, cap-to-NTP ratio, transcript design and purification method.
These points describe m7(3'-OMeG)(5')vppp(5')(2'-OMeA)pU ammonium salt or its named chemical feature. Broader product-family guidance is maintained on the category page.
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OR-CA-0005CAP 6 m7G(LNA)(5')ppp(5')(2'OMeA)pG Triammonium Salt
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OR-CA-0006CAP 7 m7G(HNA)(5')ppp(5')(2'OMeA)pG Ammonium Salt
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Product-family literature
These publications provide peer-reviewed context for the Cap Analogs product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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