OROGO PRODUCT CATEGORY

2'-O-Me Phosphoramidites

Quick view. 2′-O-methyl ribonucleoside phosphoramidites for nuclease-resistant RNA, siRNA and antisense oligonucleotide research. This category currently includes 46 products. 2'-O-Me Phosphoramidites products provide protected, sequence-addressable building blocks for solid-phase oligonucleotide synthesis and modified-sequence research.

Products46

Use scopeResearch use only

Pack sizeCustomized to requirements

SupportSelection and custom synthesis review

Category guide

Typical use

2'-O-Me Phosphoramidites products provide protected, sequence-addressable building blocks for solid-phase oligonucleotide synthesis and modified-sequence research.

How to select

Confirm base and sugar identity, protecting groups, stereochemistry, linker or label position, and compatibility with coupling and deprotection conditions.

How to qualify

Review identity, chromatographic purity, phosphorus-related quality attributes, water sensitivity and performance in a short test sequence.

Product-family considerations

Common advantages

Phosphoramidite chemistry is modular, automated and compatible with fast sequence iteration.
Modified sugar, base or linker motifs let researchers tune duplex stability, specificity, hydrophobicity, steric profile and downstream conjugation options.
Common ribose modifications can improve nuclease resistance and modulate RNA-like binding behavior.

Common limitations

Modified amidites can require adjusted coupling time, activator choice, deprotection conditions and analytical release methods.
Moisture sensitivity and storage history are important because degraded amidite can reduce coupling efficiency.

Category literature

These publications provide background for the 2'-O-Me Phosphoramidites product family. Individual product pages only show additional product- or feature-relevant references.

Selection checklist

Exact identity	Match the canonical name with a CAS number, structure, SMILES or drawing; confirm stereochemistry, protecting groups and salt form where applicable.
Specification	Define target purity, analytical method, water or residual-solvent concerns and any application-specific acceptance limits.
Workflow fit	Share the reaction, enzyme, sequence, solvent system, support or analytical method used to evaluate compatibility.
Supply need	Provide initial quantity, expected future scale, packaging preference, timeline and documentation requirements.

Product comparison

This snapshot compares up to eight products in the current catalog order. It uses published catalog fields only; confirm the exact form, pack size, specification and current availability by inquiry.

Swipe or scroll horizontally to compare all fields.

Product name	OR catalog no.	CAS	Purity / specification	Supply status	Chemical class
DMTr-2'-O-Me-rU-3'-(L)-DPSE-Phosphoramidite	OR-2OMP-0065	1528733-97-2	By inquiry	Inquiry only	Protected 2'-O-methyl ribouridine phosphoramidite
DMTr-2'-O-Me-rA(Bz)-3'-(L)-DPSE-Phosphoramidite	OR-2OMP-0066	1528733-90-5	By inquiry	Inquiry only	Protected 2'-O-methyl riboadenosine phosphoramidite
6'-O-DMTr-2'-O-Me-5'-Homo-C(Ac)-3'-CE-Phosphoramidite	OR-2OMP-0068	2714382-70-2	By inquiry	Inquiry only	Protected 2'-O-methyl-5'-homo-cytidine phosphoramidite
6'-O-DMTr-2'-O-Me-5'-Homo-G(iBu)-3'-CE-Phosphoramidite	OR-2OMP-0069	2714383-00-1	By inquiry	Inquiry only	Protected 2'-O-methyl-5'-homo-guanosine phosphoramidite
DMTr-2'-O-Me-rU-3'-(D)-DPSE-Phosphoramidite	OR-2OMP-0070	1528733-98-3	By inquiry	Inquiry only	Protected 2'-O-methyl ribouridine phosphoramidite
5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU-3'-CE-Phosphoramidite	OR-2OMP-0071	2172373-55-4	By inquiry	Inquiry only	POM-protected vinylphosphonate nucleoside phosphoramidite
DMTr-2'-O-Me-rC(Bz)-3'-CE Phosphoramidite	OR-2OMP-0072	110764-78-8	By inquiry	Inquiry only	Protected 2'-O-methyl cytidine phosphoramidite
DMTr-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite	OR-2OMP-0073	110782-31-5	By inquiry	Inquiry only	Protected 2'-O-methyl adenosine phosphoramidite

46 products

DMTr-2'-O-Me-rU-3'-(L)-DPSE-Phosphoramidite

By inquiry · CAS: 1528733-97-2

OR-2OMP-0065

DMTr-2'-O-Me-rA(Bz)-3'-(L)-DPSE-Phosphoramidite

By inquiry · CAS: 1528733-90-5

OR-2OMP-0066

6'-O-DMTr-2'-O-Me-5'-Homo-C(Ac)-3'-CE-Phosphoramidite

By inquiry · CAS: 2714382-70-2

OR-2OMP-0068

6'-O-DMTr-2'-O-Me-5'-Homo-G(iBu)-3'-CE-Phosphoramidite

By inquiry · CAS: 2714383-00-1

OR-2OMP-0069

DMTr-2'-O-Me-rU-3'-(D)-DPSE-Phosphoramidite

By inquiry · CAS: 1528733-98-3

OR-2OMP-0070

5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU-3'-CE-Phosphoramidite

By inquiry · CAS: 2172373-55-4

OR-2OMP-0071

DMTr-2'-O-Me-rC(Bz)-3'-CE Phosphoramidite

By inquiry · CAS: 110764-78-8

OR-2OMP-0072

DMTr-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite

By inquiry · CAS: 110782-31-5

OR-2OMP-0073

DMTr-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite

By inquiry · CAS: 199593-09-4

OR-2OMP-0074

DMTr-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite

By inquiry · CAS: 150780-67-9

OR-2OMP-0075

DMTr-2'-O-Me-rU-3'-CE-Phosphoramidite

By inquiry · CAS: 110764-79-9

OR-2OMP-0076

5'-O-DMTr-(5'S)-5'-C-methyl-2'-O-methyl-N4-acetylcytidine-3'-CE phosphoramidite

By inquiry · CAS: 1883486-16-5

OR-2OMP-0044

5'-O-DMTr-(5'S)-5'-C-methyl-2'-O-methyluridine-3'-CE phosphoramidite

By inquiry · CAS: 2747890-15-7

OR-2OMP-0046

4'-O-[(Dimethoxyphosphoryl)methyl]-2'-O-methyluridine-3'-CE-Phosphoramidite

By inquiry · CAS: 2197181-94-3

OR-2OMP-0015

Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite

By inquiry · CAS: 2419895-65-9

OR-2OMP-0019

Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rC(Bz)-3'-CE-Phosphoramidite

By inquiry · CAS: N/A

OR-2OMP-0020

Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite

By inquiry · CAS: N/A

OR-2OMP-0021

5'-O-DMTr-(5'S)-5'-C-methyl-2'-O-methyl-N6-benzoyladenosine-3'-CE phosphoramidite

By inquiry · CAS: 3060423-81-3

OR-2OMP-0043

5'-O-DMTr-(5'S)-5'-C-methyl-2'-O-methyl-N2-isobutyrylguanosine-3'-CE phosphoramidite

By inquiry · CAS: N/A

OR-2OMP-0045

5'-O-(Methacrylamide-functionalized trityl)-2'-O-methyluridine-3'-CE phosphoramidite

By inquiry · CAS: N/A

OR-2OMP-0047

Chemical structure of 4'-O-[(Hydroxy(methoxy)phosphoryl)methyl]-2'-O-methyluridine-3'-CE-Phosphoramidite

4'-O-[(Hydroxy(methoxy)phosphoryl)methyl]-2'-O-methyluridine-3'-(2-cyanoethyl N,N-diisopropylphosphoramidite)

By inquiry · CAS: N/A

OR-2OMP-0016

Chemical structure of 5'-Deoxy-5'-[(dimethoxyphosphoryl)methyl]-2'-O-methyluridine-3'-CE-Phosphoramidite

5'-Deoxy-5'-[(dimethoxyphosphoryl)methyl]-2'-O-methyluridine-3'-(2-cyanoethyl N,N-diisopropylphosphoramidite)

By inquiry · CAS: N/A

OR-2OMP-0017

5'-O-DMTr-2'-O-Me-6-[3-(3-methoxy-3-oxopropyl)phenyl]purine riboside-3'-CE-Phosphoramidite

By inquiry · CAS: N/A

OR-2OMP-0025

5'-O-DMTr-2'-O-Me-N2,N6-bis(isobutyryl)-2-aminoadenosine-3'-CE-Phosphoramidite

By inquiry · CAS: 160526-51-2

OR-2OMP-0026

5'-O-DMTr-2'-O-Me-N2-isobutyrylguanosine-3'-(L)-PSM phosphoramidite

By inquiry · CAS: N/A

OR-2OMP-0038

5'-O-DMTr-2'-O-Me-uridine-3'-(L)-PSM phosphoramidite

By inquiry · CAS: 2963598-67-4

OR-2OMP-0041

5'-O-DMTr-(5'R)-5'-C-methyl-2'-O-methyl-N6-benzoyladenosine-3'-CE phosphoramidite

By inquiry · CAS: 3055727-88-0

OR-2OMP-0042

2'-O-Me-2-thio-U-3'-phosphoramidite

By inquiry · CAS: 302918-84-9

OR-2MEP-0004

6'-O-DMTr-2'-O-Me-5'-Homo-A(Bz)-3'-CE-Phosphoramidite

By inquiry · CAS: 2750354-56-2

OR-2OMP-0023

6'-O-DMTr-2'-O-Me-5'-Homo-U-3'-CE-Phosphoramidite

By inquiry · CAS: 2714382-62-2

OR-2OMP-0024

5'-O-DMTr-2'-O-Me-N6-benzoyl-N6-methyladenosine-3'-CE-Phosphoramidite

By inquiry · CAS: 2659239-32-2

OR-2OMP-0028

5'-O-DMTr-2'-O-methylpseudouridine-3'-CE-Phosphoramidite

By inquiry · CAS: 199737-09-2

OR-2OMP-0029

5'-O-DMTr-2'-O-Me-N6-benzoyladenosine-3'-(D)-DPSE phosphoramidite

By inquiry · CAS: 1528733-91-6

OR-2OMP-0030

5'-O-DMTr-2'-O-Me-N6-benzoyladenosine-3'-(D)-PSM phosphoramidite

By inquiry · CAS: 2379296-27-0

OR-2OMP-0031

5'-O-DMTr-2'-O-Me-N6-benzoyladenosine-3'-(L)-PSM phosphoramidite

By inquiry · CAS: 2379296-17-8

OR-2OMP-0032

DMTr-2'-O-Me-rG(dmf)-3'-CE-Phosphoramidite

By inquiry · CAS: 128219-77-2

OR-2OMP-0035

5'-O-DMTr-2'-O-Me-N2-isobutyrylguanosine-3'-(D)-DPSE phosphoramidite

By inquiry · CAS: 2227139-99-1

OR-2OMP-0036

DMTr-2'-O-Me-rI-3'-CE-Phosphoramidite

By inquiry · CAS: 128219-85-2

OR-2OMP-0039

5'-O-DMTr-2'-O-Me-N2-isobutyryl-N6-[(dimethylamino)methylene]-2-aminoadenosine-3'-CE-Phosphoramidite

By inquiry · CAS: N/A

OR-2OMP-0027

DMTr-2'-O-Me-rC(Ac)-3'-(L)-PSM-Phosphoramidite

By inquiry · CAS: N/A

OR-2OMP-0033

5'-O-DMTr-2'-O-Me-N2-isobutyrylguanosine-3'-(L)-DPSE phosphoramidite

By inquiry · CAS: 2227139-95-7

OR-2OMP-0037

5'-O-DMTr-N4-benzoyl-5-methyl-2'-O-methylcytidine-3'-CE phosphoramidite

By inquiry · CAS: 166593-57-3

OR-2OMP-0055

5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-N6-methyladenosine 3'-CED phosphoramidite

By inquiry · CAS: 2348385-04-4

OR-2MEP-0003

N2,N6-Diphenoxyacetyl-5'-O-DMTr-2'-O-methyl-2,6-diaminopurine riboside 3'-CE phosphoramidite

By inquiry · CAS: N/A

OR-2MEP-0002

5-Methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine 3'-CE phosphoramidite

By inquiry · CAS: N/A

OR-2MEP-0001

5'-O-DMTr-5-methyl-2'-O-methyluridine-3'-CE phosphoramidite

By inquiry · CAS: N/A

OR-2OMP-0056

Frequently asked questions

What are typical uses for 2'-O-Me Phosphoramidites?

2'-O-Me Phosphoramidites products provide protected, sequence-addressable building blocks for solid-phase oligonucleotide synthesis and modified-sequence research.

What should be confirmed before ordering 2'-O-Me Phosphoramidites?

Confirm base and sugar identity, protecting groups, stereochemistry, linker or label position, and compatibility with coupling and deprotection conditions.

Are custom quantities or related analogs available?

OROGO reviews custom package sizes, catalog-adjacent analogs and research-use custom synthesis requests against the target structure, purity, scale and timeline.

Need help selecting a product?

Tell our scientists about your target chemistry, workflow, required purity and scale. We can help identify a catalog product, related analog or custom route.

Talk to a scientist Browse the complete catalog

2'-O-Me Phosphoramidites

Category guide

Product-family considerations

Category literature

Selection checklist

Product comparison

46 products

Related technical articles

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Oligonucleotide Capacity Is Measured in Moles, and the Numbers Are Small

Arrowhead's P=S Detour to a 5′-Cyclopropyl Phosphonate

Frequently asked questions

Need help selecting a product?

Related technical guides

How to evaluate phosphoramidites

Working with stereodefined phosphorothioate