2'-O-Me Phosphoramidites
Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rC(Bz)-3'-CE-Phosphoramidite
Quick view. An N4-benzoyl 2'-O-methyl cytidine CE phosphoramidite bearing an E-configured vinyl phosphonate masked with two POM groups for oligonucleotide synthesis research. CAS N/A. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rC(Bz)-3'-CE-Phosphoramidite is classified as 2'-o-me phosphoramidites (Formula C39H57N5O13P2; molecular weight 865.85).
Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rC(Bz)-3'-CE-Phosphoramidite — Bis(POM)-masked E-vinylphosphonate 2'-O-methyl cytidine building block for solid-phase oligonucleotide synthesis research.
For Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rC(Bz)-3'-CE-Phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rC(Bz)-3'-CE-Phosphoramidite
Useful catalog search terms
- C39H57N5O13P2
- JCWBJBRNLLVLQY-ZUZGDNAQSA-N
Physicochemical data
| CAS status | No public CAS assigned |
|---|---|
| InChIKey | JCWBJBRNLLVLQY-ZUZGDNAQSA-N |
| Vinyl geometry | E |
| Phosphonate masking | Two pivaloyloxymethyl (POM) groups |
| Base protection | N4-benzoyl |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rC(Bz)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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