Thio Phosphoramidites
N6-Benzoyl-5'-O-DMTr-2'-O-MOE-adenosine-3'-PS phosphoramidite
Quick view. A protected adenosine building block bearing N6-benzoyl, 5'-O-DMTr, and 2'-O-methoxyethyl groups with a 3'-S-(2-benzoylmercaptoethyl) pyrrolidino thiophosphoramidite functionality. CAS 2360826-72-6. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
N6-Benzoyl-5'-O-DMTr-2'-O-MOE-adenosine-3'-PS phosphoramidite is classified as thio phosphoramidites (Formula C54H57N6O9PS2; molecular weight 1029.18).
N6-Benzoyl-5'-O-DMTr-2'-O-MOE-adenosine-3'-PS phosphoramidite — Identity-defined 2'-O-MOE-rA(Bz)-3'-PS phosphoramidite for research workflows involving solid-phase oligonucleotide synthesis.
For N6-Benzoyl-5'-O-DMTr-2'-O-MOE-adenosine-3'-PS phosphoramidite, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 2'-O-MOE-rA(Bz)-3'-PS phosphoramidite
- 5'-DMT-2'-O-MOE-A(Bz)-3'-PS phosphoramidite
- N6-Bz-5'-O-DMTr-2'-O-MOE-rA-3'-PS amidite
Useful catalog search terms
- CAS 2360826-72-6
Physicochemical data
| InChIKey | OKYFNXWXBWXJHI-QRWWDSLFSA-N |
|---|---|
| Nucleoside | Adenosine |
| Base protection | N6-Benzoyl |
| 5' protection | DMTr |
| 2' modification | O-Methoxyethyl (MOE) |
| 3' functionality | S-(2-benzoylmercaptoethyl) pyrrolidino thiophosphoramidite |
| InChI | InChI=1S/C54H57N6O9PS2/c1-63-31-32-66-48-47(69-70(59-29-13-14-30-59)72-34-33-71-53(62)39-17-9-5-10-18-39)45(68-52(48)60-37-57-46-49(55-36-56-50(46)60)58-51(61)38-15-7-4-8-16-38)35-67-54(40-19-11-6-12-20-40,41-21-25-43(64-2)26-22-41)42-23-27-44(65-3)28-24-42/h4-12,15-28,36-37,45,47-48,52H,13-14,29-35H2,1-3H3,(H,55,56,58,61)/t45-,47-,48-,52-,70?/m1/s1 |
| SMILES | C(C1=CC=CC=C1)(SCCSP(N1CCCC1)O[C@@H]1[C@H](O[C@H]([C@@H]1OCCOC)N1C2=NC=NC(=C2N=C1)NC(C1=CC=CC=C1)=O)COC(C1=CC=CC=C1)(C1=CC=C(C=C1)OC)C1=CC=C(C=C1)OC)=O |
| Canonical SMILES | C(C1=CC=CC=C1)(SCCSP(N1CCCC1)O[C@@H]1[C@H](O[C@H]([C@@H]1OCCOC)N1C2=NC=NC(=C2N=C1)NC(C1=CC=CC=C1)=O)COC(C1=CC=CC=C1)(C1=CC=C(C=C1)OC)C1=CC=C(C=C1)OC)=O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe N6-Benzoyl-5'-O-DMTr-2'-O-MOE-adenosine-3'-PS phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Thio Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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