DMTr-protected Nucleosides
3'-O-DMTr-2'-O-Me-rU
Quick view. 2'-O-methyluridine bearing a 3'-O-DMTr group and a free 5'-hydroxyl. CAS N/A. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
3'-O-DMTr-2'-O-Me-rU is classified as dmtr-protected nucleosides.
3'-O-DMTr-2'-O-Me-rU supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 3'-O-DMTr-2'-O-Me-rU, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 3'-O-DMTr-2'-O-methyluridine
- 3'-O-DMT-2'-O-Me-rU
Physicochemical data
| Nucleoside | Uridine |
|---|---|
| Sugar modification | 2'-O-methyl |
| Hydroxyl protection | 3'-O-DMTr |
| Hydroxyl state | 5' hydroxyl group unprotected |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 3'-O-DMTr-2'-O-Me-rU or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.