DMTr-protected Nucleosides
5'-O-DMTr-2'-F-dC(Bz)
Quick view. N4-benzoyl-protected 2'-fluoro-2'-deoxycytidine bearing a 5'-O-DMTr group and a free 3'-hydroxyl. CAS N/A. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-O-DMTr-2'-F-dC(Bz) is classified as dmtr-protected nucleosides.
5'-O-DMTr-2'-F-dC(Bz) is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 5'-O-DMTr-2'-F-dC(Bz), coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMT-2'-F-dC(Bz)
Physicochemical data
| Nucleoside | 2'-fluoro-2'-deoxycytidine |
|---|---|
| Base protection | N4-benzoyl |
| Hydroxyl protection | 5'-O-DMTr |
| Hydroxyl state | 3' hydroxyl group unprotected |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5'-O-DMTr-2'-F-dC(Bz) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.