Other Phosphoramidites
3'-O-Me-U-2'-phosphoramidite
Quick view. A 5'-O-DMTr-protected 3'-O-methyluridine 2'-O-CED phosphoramidite, CAS 179479-05-1. CAS 179479-05-1. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
3'-O-Me-U-2'-phosphoramidite is classified as other phosphoramidites (Formula C40H49N4O9P; molecular weight 760.81).
3'-O-Me-U-2'-phosphoramidite can be evaluated in terminally blocked nucleotide, cap-chemistry and analytical-reference workflows where 3′-O-methylation changes extension or end-group reactivity.
For 3'-O-Me-U-2'-phosphoramidite, the 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMTr-3'-O-methyluridine-2'-CED-phosphoramidite
- Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-methyl-, 2'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
Useful catalog search terms
- 3'-OMe-U-2'-phosphoramidite
- CAS 179479-05-1
- C40H49N4O9P
- FPRLFGWVAXFXTL-XKZJCBTISA-N
Physicochemical data
| Nucleoside | Uridine |
|---|---|
| Protection pattern | 5'-O-DMTr and 3'-O-methyl |
| 2' functionality | 2-Cyanoethyl N,N-diisopropylphosphoramidite |
| Phosphorus stereochemistry | Unspecified |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
Method limitations
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
These points describe 3'-O-Me-U-2'-phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Other Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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