Cap Analogs
m7G(5')vppp(5')(2'-OMeA)pG triammonium
Quick view. A vinyl-linked CAP5011 cap analog associated with CAS 3038327-80-6 and presented in triammonium form for mRNA-synthesis research. CAS 3038327-80-6. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
m7G(5')vppp(5')(2'-OMeA)pG triammonium is classified as cap analogs.
m7G(5')vppp(5')(2'-OMeA)pG triammonium — Modified trinucleotide cap analog for mRNA-synthesis research.
For m7G(5')vppp(5')(2'-OMeA)pG triammonium, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- CAP 5 m7G(5')vppp(5')(2'OMeA)pG Ammonium Salt
- CAP 5
- CAP5011
Useful catalog search terms
- CAS 3038327-80-6
Physicochemical data
| Inner-salt formula | C33H43N15O23P4 |
|---|---|
| Inner-salt molecular weight | 1141.68 |
| Counterion form | Triammonium |
| CAS scope | CAP5011 core identity; counterion composition not fixed by CAS |
| Nucleotide shorthand | m7G(5')vppp(5')(2'-OMeA)pG |
| Cap linkage | Vinyl-linked m7G triphosphate |
| First transcribed nucleotide | 2'-O-methyladenosine |
| Covalent InChIKey | FZDGGNDFFHPRBY-SWKUTIIRSA-O |
| Covalent InChI | InChI=1S/C33H43N15O23P4/c1-45-10-48(26-16(45)28(54)44-33(36)42-26)30-19(51)17(49)11(66-30)3-4-72(55,56)70-75(61,62)71-74(59,60)65-6-13-21(22(63-2)31(68-13)46-8-39-14-23(34)37-7-38-24(14)46)69-73(57,58)64-5-12-18(50)20(52)29(67-12)47-9-40-15-25(47)41-32(35)43-27(15)53/h3-4,7-13,17-22,29-31,49-52H,5-6H2,1-2H3,(H11-,34,35,36,37,38,41,42,43,44,53,54,55,56,57,58,59,60,61,62)/p+1/b4-3+/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1 |
| Covalent SMILES | CO[C@@H]1[C@H](OP(=O)(O)OC[C@H]2O[C@@H](n3cnc4c(=O)nc(N)[nH]c43)[C@H](O)[C@@H]2O)[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)/C=C/[C@H]2O[C@@H](n3c[n+](C)c4c(=O)nc(N)[nH]c43)[C@H](O)[C@@H]2O)O[C@H]1n1cnc2c(N)ncnc21 |
| Canonical covalent SMILES | CO[C@@H]1[C@H](OP(=O)(O)OC[C@H]2O[C@@H](n3cnc4c(=O)nc(N)[nH]c43)[C@H](O)[C@@H]2O)[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)/C=C/[C@H]2O[C@@H](n3c[n+](C)c4c(=O)nc(N)[nH]c43)[C@H](O)[C@@H]2O)O[C@H]1n1cnc2c(N)ncnc21 |
| Triammonium molecular formula | C33H52N18O23P4 |
| Formula basis | Triammonium form |
| Triammonium molecular weight | 1192.77 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
- Cap analog selection can influence capping efficiency, orientation and downstream translation-related performance.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
- Capping outcome depends on polymerase system, cap-to-NTP ratio, transcript design and purification method.
These points describe m7G(5')vppp(5')(2'-OMeA)pG triammonium or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Cap Analogs product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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