Nucleoside Protection & Derivatization Reagents
1-(Trifluoroacetyl)imidazole (TFAI)
Quick view. A trifluoroacetylating reagent used for derivatization of aminomethyl side chains in certain nucleoside substrates. CAS 1546-79-8. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
1-(Trifluoroacetyl)imidazole (TFAI) is classified as nucleoside protection & derivatization reagents (Formula C5H3F3N2O; molecular weight 164.09).
1-(Trifluoroacetyl)imidazole (TFAI) — Trifluoroacetylation of aminomethyl side chains in certain nucleoside substrates.
For 1-(Trifluoroacetyl)imidazole (TFAI), coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- TFAI
- N-Trifluoroacetylimidazole
- 1-(Trifluoroacetyl)-1H-imidazole
- 1H-Imidazole, 1-(trifluoroacetyl)-
Useful catalog search terms
- 1-(Trifluoroacetyl)imidazole
- CAS 1546-79-8
- PubChem CID 73767
Physicochemical data
| PubChem CID | 73767 |
|---|---|
| InChIKey | SINBGNJPYWNUQI-UHFFFAOYSA-N |
| IUPAC name | 2,2,2-trifluoro-1-imidazol-1-ylethanone |
| SMILES | C1=CN(C=N1)C(=O)C(F)(F)F |
| Reagent class | Trifluoroacetylating reagent |
| InChI | InChI=1S/C5H3F3N2O/c6-5(7,8)4(11)10-2-1-9-3-10/h1-3H |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 1-(Trifluoroacetyl)imidazole (TFAI) or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
Product-family literature
These publications provide peer-reviewed context for the Nucleoside Protection & Derivatization Reagents product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.