2'-FANA Nucleosides
2'-Deoxy-2'-fluoro-beta-D-arabino-2-thiouridine
Quick view. A 2'-fluoro-beta-D-arabino-2-thiouridine nucleoside, CAS 1006872-85-0, with formula C9H11FN2O4S. CAS 1006872-85-0. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2'-Deoxy-2'-fluoro-beta-D-arabino-2-thiouridine is classified as 2'-fana nucleosides (Formula C9H11FN2O4S; molecular weight 262.26).
2'-Deoxy-2'-fluoro-beta-D-arabino-2-thiouridine — A fluorinated thiouridine nucleoside building block for research in modified nucleoside and oligonucleotide chemistry.
For 2'-Deoxy-2'-fluoro-beta-D-arabino-2-thiouridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-sulfanylidenepyrimidin-4-one
- 2'-Deoxy-2'-fluoro-b-D-arabino-2-thiouridine
Useful catalog search terms
- 1006872-85-0
- PubChem CID 168448593
- OR-2FAN-0040
Physicochemical data
| PubChem CID | 168448593 |
|---|---|
| InChIKey | ADLOOJJGYVNUTC-PXBUCIJWSA-N |
| Nucleoside | 2-Thiouridine |
| Sugar modification | 2'-deoxy-2'-fluoro-beta-D-arabino configuration |
| InChI | InChI=1S/C9H11FN2O4S/c10-6-7(15)4(3-13)16-8(6)12-2-1-5(14)11-9(12)17/h1-2,4,6-8,13,15H,3H2,(H,11,14,17)/t4-,6+,7-,8-/m1/s1 |
| SMILES | C1=CN(C(=S)NC1=O)[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-Deoxy-2'-fluoro-beta-D-arabino-2-thiouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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