2'-O-Propargyl Nucleosides
2'-O-Propargyluridine
Quick view. 2'-O-Propargyluridine is a terminal-alkyne-bearing nucleoside building block for research-use modified-nucleoside and oligonucleotide chemistry. CAS 129778-58-1. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2'-O-Propargyluridine is classified as 2'-o-propargyl nucleoside (Formula C12H14N2O6; molecular weight 282.25).
2'-O-Propargyluridine — A terminal-alkyne-bearing uridine building block for research-use modified-nucleoside and oligonucleotide chemistry.
For 2'-O-Propargyluridine, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- 2'-O-propargyl-rU
- 2'-O-propargyl-Ur
- Uridine, 2'-O-2-propyn-1-yl-
Useful catalog search terms
- CAS 129778-58-1
Physicochemical data
| PubChem CID | 15747441 |
|---|---|
| InChIKey | SJIYVXTZWZSVLZ-QCNRFFRDSA-N |
| Modification | propargyl ether at the ribose 2'-oxygen |
| InChI | InChI=1S/C12H14N2O6/c1-2-5-19-10-9(17)7(6-15)20-11(10)14-4-3-8(16)13-12(14)18/h1,3-4,7,9-11,15,17H,5-6H2,(H,13,16,18)/t7-,9-,10-,11-/m1/s1 |
| SMILES | C#CCO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)CO)O |
| Canonical SMILES | C#CCO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)CO)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
These points describe 2'-O-Propargyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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