Succinates
DMTr-2'-OMe-C(Ac)-3'-Succinate
Quick view. DMTr-2'-OMe-C(Ac)-3'-Succinate is a protected 2'-O-methylcytidine derivative bearing 5'-O-DMTr, N4-acetyl, and 3'-O-succinate groups in the free-acid form. The reviewed identity corresponds to PubChem CID 138376011. CAS 2746380-46-9. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
DMTr-2'-OMe-C(Ac)-3'-Succinate is classified as protected 2'-o-methylcytidine 3'-o-succinate (Formula C37H39N3O11; molecular weight 701.70).
DMTr-2'-OMe-C(Ac)-3'-Succinate supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For DMTr-2'-OMe-C(Ac)-3'-Succinate, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMTr-2'-O-methyl-N4-acetylcytidine-3'-succinate
Useful catalog search terms
- CAS 2746380-46-9
- Succinates
Physicochemical data
| PubChem CID | 138376011 |
|---|---|
| InChIKey | APTHLBJVRAHHIM-QCSZPJFZSA-N |
| Structural features | 5'-O-DMTr; 2'-O-methyl; N4-acetyl cytosine; 3'-O-succinate; free carboxylic acid |
| InChI | InChI=1S/C37H39N3O11/c1-23(41)38-30-20-21-40(36(45)39-30)35-34(48-4)33(51-32(44)19-18-31(42)43)29(50-35)22-49-37(24-8-6-5-7-9-24,25-10-14-27(46-2)15-11-25)26-12-16-28(47-3)17-13-26/h5-17,20-21,29,33-35H,18-19,22H2,1-4H3,(H,42,43)(H,38,39,41,45)/t29-,33-,34-,35-/m1/s1 |
| SMILES | CC(=O)NC1=NC(=O)N(C=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OC(=O)CCC(=O)O)OC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe DMTr-2'-OMe-C(Ac)-3'-Succinate or its named chemical feature. Broader product-family guidance is maintained on the category page.
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OR-SUCC-0003DMTr-2'-F-dA(Bz)-3'-succinate, TEA salt
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OR-SUCC-0004DMTr-2'-F-dC(Ac)-3'-succinate, TEA salt
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OR-SUCC-0005DMTr-2'-F-dG(iBu)-3'-succinate, TEA salt
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Product-family literature
These publications provide peer-reviewed context for the Succinates product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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