Protected Nucleosides
3'-O-TBDMS-thymidine
Quick view. A thymidine building block bearing a 3'-O-TBDMS protecting group and a free 5'-hydroxyl group. CAS 40733-27-5. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
3'-O-TBDMS-thymidine is classified as protected nucleosides (Formula C16H28N2O5Si; molecular weight 356.49).
3'-O-TBDMS-thymidine — Identity-defined 3'-O-protected thymidine building block for research workflows involving nucleoside, nucleotide, and oligonucleotide chemistry.
For 3'-O-TBDMS-thymidine, confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- 3'-O-TBDMS-2'-dT
- 3'-O-tert-Butyldimethylsilylthymidine
- Thymidine 3'-O-TBDMS
Useful catalog search terms
- CAS 40733-27-5
Physicochemical data
| InChIKey | QAPSNMNOIOSXSQ-YNEHKIRRSA-N |
|---|---|
| Nucleoside | Thymidine (2'-deoxythymidine) |
| Sugar protection | 3'-O-TBDMS |
| Free hydroxyl group | 5' |
| InChI | InChI=1S/C16H28N2O5Si/c1-10-8-18(15(21)17-14(10)20)13-7-11(12(9-19)22-13)23-24(5,6)16(2,3)4/h8,11-13,19H,7,9H2,1-6H3,(H,17,20,21)/t11-,12+,13+/m0/s1 |
| SMILES | CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)O[Si](C)(C)C(C)(C)C |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
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Product-family literature
These publications provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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