Protected Nucleosides
3'-O-TBDMS-2'-O-Me-rG(iBu)
Quick view. N2-Isobutyryl-2'-O-methylguanosine bearing a 3'-O-TBDMS group with a free 5'-hydroxyl group. CAS 863097-97-6. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
3'-O-TBDMS-2'-O-Me-rG(iBu) is classified as protected nucleosides (Formula C21H35N5O6Si; molecular weight 481.63).
3'-O-TBDMS-2'-O-Me-rG(iBu) supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 3'-O-TBDMS-2'-O-Me-rG(iBu), excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- N2-Isobutyryl-3'-O-TBDMS-2'-O-methylguanosine
Useful catalog search terms
- CAS 863097-97-6
Physicochemical data
| Nucleoside | N2-Isobutyryl-2'-O-methylguanosine |
|---|---|
| Hydroxyl protection | 3'-O-TBDMS |
| Hydroxyl state | 5' hydroxyl group unprotected |
| SMILES | CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[Si](C)(C)C(C)(C)C)OC |
| InChI | InChI=1S/C21H35N5O6Si/c1-11(2)17(28)24-20-23-16-13(18(29)25-20)22-10-26(16)19-15(30-6)14(12(9-27)31-19)32-33(7,8)21(3,4)5/h10-12,14-15,19,27H,9H2,1-8H3,(H2,23,24,25,28,29)/t12-,14-,15-,19-/m1/s1 |
| InChIKey | CEEYEENCDIBWAI-QEPJRFBGSA-N |
| PubChem CID | 136408514 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 3'-O-TBDMS-2'-O-Me-rG(iBu) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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