3'-O-TBDMS Phosphoramidites
N2-Isobutyryl-5'-O-DMTr-3'-O-TBDMS-guanosine-2'-CE phosphoramidite
Quick view. A protected guanosine building block bearing N2-isobutyryl, 5'-O-DMTr, and 3'-O-TBDMS groups with a 2'-cyanoethyl N,N-diisopropylphosphoramidite functionality. CAS 1445905-51-0. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
N2-Isobutyryl-5'-O-DMTr-3'-O-TBDMS-guanosine-2'-CE phosphoramidite is classified as 3'-o-tbdms phosphoramidites (Formula C50H68N7O9PSi; molecular weight 970.18).
N2-Isobutyryl-5'-O-DMTr-3'-O-TBDMS-guanosine-2'-CE phosphoramidite — Identity-defined 3'-O-TBDMS guanosine 2'-phosphoramidite for research workflows involving solid-phase oligonucleotide synthesis.
For N2-Isobutyryl-5'-O-DMTr-3'-O-TBDMS-guanosine-2'-CE phosphoramidite, confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- 3'-O-TBDMS-rG(iBu) phosphoramidite
- 3'-TBDMS-iBu-rG phosphoramidite
- DMT-3'-O-TBDMS-G(iBu)-2'-CE phosphoramidite
Useful catalog search terms
- CAS 1445905-51-0
Physicochemical data
| InChIKey | JCCWPNDXSMAHGZ-FTZVBZPOSA-N |
|---|---|
| PubChem CID | 135742514 |
| Nucleoside | Guanosine |
| Base protection | N2-Isobutyryl |
| 5' protection | DMTr |
| 3' protection | TBDMS |
| 2'-Coupling group | 2-Cyanoethyl N,N-diisopropylphosphoramidite |
| MDL number | MFCD30475539 |
| InChI | InChI=1S/C50H68N7O9PSi/c1-32(2)45(58)54-48-53-44-41(46(59)55-48)52-31-56(44)47-43(65-67(63-29-17-28-51)57(33(3)4)34(5)6)42(66-68(12,13)49(7,8)9)40(64-47)30-62-50(35-18-15-14-16-19-35,36-20-24-38(60-10)25-21-36)37-22-26-39(61-11)27-23-37/h14-16,18-27,31-34,40,42-43,47H,17,29-30H2,1-13H3,(H2,53,54,55,58,59)/t40-,42-,43-,47-,67?/m1/s1 |
| SMILES | CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O[Si](C)(C)C(C)(C)C)OP(N(C(C)C)C(C)C)OCCC#N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Related products
Product-family literature
These publications provide peer-reviewed context for the 3'-O-TBDMS Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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