Intermediates
3'-OMe-m7GDP TEA Salt
Quick view. A triethylammonium salt form of 3'-O-methyl-N7-methylguanosine 5'-diphosphate. CAS 400806-44-2, formula and molecular weight refer to the inner-salt parent, while TEA stoichiometry is unspecified. CAS 400806-44-2. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
3'-OMe-m7GDP TEA Salt is classified as intermediates (Formula C12H19N5O11P2; molecular weight 471.26).
3'-OMe-m7GDP TEA Salt can be evaluated in terminally blocked nucleotide, cap-chemistry and analytical-reference workflows where 3′-O-methylation changes extension or end-group reactivity.
For 3'-OMe-m7GDP TEA Salt, the 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
Names and search terms
Confirmed or normalized name variants
- Guanosine 5'-(trihydrogen diphosphate), 7-methyl-3'-O-methyl-, inner salt (9CI)
Useful catalog search terms
- 3'-O-methyl-N7-methylguanosine 5'-diphosphate
- CAS 400806-44-2
Physicochemical data
| Parent identity | 3'-O-methyl-N7-methylguanosine 5'-diphosphate inner salt |
|---|---|
| Salt form | Triethylammonium salt; TEA stoichiometry unspecified |
| Modification pattern | 3'-O-methyl and N7-methyl |
| Phosphate state | 5'-diphosphate |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
- Cap analog selection can influence capping efficiency, orientation and downstream translation-related performance.
Method limitations
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
- Capping outcome depends on polymerase system, cap-to-NTP ratio, transcript design and purification method.
These points describe 3'-OMe-m7GDP TEA Salt or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Intermediates product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.